Abstract
Constitutively expressed Fas ligand (FasL) in several distinct epithelial cell types appears to protect tissues by inducing apoptosis of Fas+ immune cells during inflammatory reactions. To study the relationship of FasL and inflammation process in cornea, we examined the effects of inflammatory cytokine IL-1β on the FasL production, expression and cytotoxic function in corneal endothelial cells. In this paper, we demonstrate that IL-1β inhibits the FasL production and expression in corneal endothelial cells. The promoter activities of FasL in these cells are reduced by IL-1β in a dose-dependent manner. Finally, we also find that IL-1β block the cytotoxic effects of FasL derived from corneal endothelial cells to the Fas+ target cells. These data support the view that FasL derived from corneal endothelial cells modulate inflammation within cornea.
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