Abstract
IL-8 (Chemokine) stimulate the recruitment of inflammatory cells and thus known to play a major role in the initiation and progression of any inflammation, Current systematic review aimed in finding role of salivary IL-8 as a biomarker in Periodontal Diseases, despite of having an important role in the pathogenesis of Periodontal diseases only few studies were done till date to find its co-relation with Periodontitis, Electronic searches of the PubMed, and Scopus databases were conducted from 2000 to 2016 for literature detecting IL-8 levels in individuals with CP compared with healthy individuals in the saliva of the patients. Only 5 Publications till date reported with levels of salivary Il-8 in CP, overall systematic review reported contradictory findings regarding IL-8 levels in patients with Chronic Periodontitis when compared with healthy controls, thus more number of longitudinal studies are required to conform the exact co-relation.
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