IL-2 gene transfer for chemosensitization of multidrug-resistant human colon carcinoma cells.

Abstract

Multidrug resistance (MDR) represents a major obstacle to efficient cancer chemotherapy. This phenomenon is often associated with overexpression of a variety of MDR-associated genes such as the multidrug resistance gene 1 (mdr1) [1,2], the gene for the multidrug resistance-associated protein (MRP) [1,3] and/or the gene for the lung resistance protein (LRP) [1,4]. The mdrl and MRP genes code for energy-dependent efflux pumps [1–3], the LRP gene encodes a vault protein [1,4]. However, all of these products may contribute to the establishment of the MDR phenotype in resistant tumor cells.KeywordsMultidrug ResistanceColon Carcinoma Cell LineHuman Colon Carcinoma CellMultidrug Resistance GeneFACScan AnalysisThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.