Abstract
Introduction Proinflammatory cytokines have been implicated in the pathogenesis of acute kidney allograft rejection. The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-α -308 promoter polymorphisms and acute kidney allograft rejection. Methods The study included 72 patients with long-term stable graft function, and 57 diagnosed with acute kidney allograft rejection. Results Patients with acute kidney allograft rejection showed a prevalence of subjects with TNF-α T2 allele ( P < .05). The risk of acute kidney allograft rejection diagnosis was 2.5-fold greater among carriers of the T2 allele than those homozygous for T1T1 (OR 2.53, 95% CI 1.19 to 5.37, P < .05) There was no statistically significant difference in the distribution of IL-2 genotypes between patients with stable graft function and acute kidney allograft rejection. Conclusion The results suggest that TNF-α -308 promoter polymorphism is a risk factor for acute kidney allograft rejection.
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