IL-17A�producing CD8+ T cells in psoriasis: correlation with psoriasis severity and relationship with MAIT cell lineage

Abstract

Event Abstract Back to Event IL-17A–producing CD8+ T cells in psoriasis: correlation with psoriasis severity and relationship with MAIT cell lineage Marcel B. Teunissen1*, Nataliya G. Yeremenko2, Dominique L. Baeten2, Saskia Chielie1, Phyllis I. Spuls1, Menno A. De Rie1 and Pieter C. Res1 1 Academic Medical Center, Dermatology, Netherlands 2 Academic medical Center, Clinical Immunology and Rheumatology, Netherlands Our observation that IL-17A–producing CD8+ T cells are overrepresented in psoriatic lesions is in line with the general consensus that T cells and IL-17A are critically involved in psoriasis. Here we provide further proof that CD8+ T cells are involved in the pathogenesis and analyzed T cells derived from peripheral blood and lesional dermis and epidermis by flow cytometry. The frequency of IL-17A–producing CD8+ T cells in blood correlated with psoriasis severity. Such correlation was not found for IL-22–producing CD8+ and CD4+ T cells. Of note, a remarkable higher frequency of skin-homing molecule CLA was found in IL-17A and/or IL-22 producing CD8+ blood T cells of psoriasis patients. However, this feature was also observed in healthy individuals. IL-17A–producing CD8+ T cells in blood have been described to belong to the mucosa-associated invariant T (MAIT) cell lineage, expressing the invariant T cell receptor Vα7.2-Jα33 chain, CD161 (high) and IL-18Rα. We unequivocally show the presence of MAIT cells in psoriatic as well as healthy skin. IL-17A–producing CD8+ MAIT cells were only present in psoriatic lesional skin, suggesting contribution to psoriasis development. IL-17A was also expressed by a considerable proportion of CD8+ T cells without MAIT cell characteristics, likely containing MHC class I-restricted psoriasis-associated autoreactive T cells. In conclusion, we provide supporting evidence that implicates conventional CD8+ T cells in the pathogenesis of psoriasis and describe the presence of innate MAIT cells in psoriatic lesions as an additional source of IL-17, a feature that was not appreciated before. Keywords: Psoriasis, IL-17A, MAIT cell, CD8+ T cell, T cell receptor Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Teunissen MB, Yeremenko NG, Baeten DL, Chielie S, Spuls PI, De Rie MA and Res PC (2013). IL-17A–producing CD8+ T cells in psoriasis: correlation with psoriasis severity and relationship with MAIT cell lineage. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00786 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Marcel B Teunissen, Academic Medical Center, Dermatology, Amsterdam, 1105 AZ, Netherlands, m.b.teunissen@amsterdamumc.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marcel B Teunissen Nataliya G Yeremenko Dominique L Baeten Saskia Chielie Phyllis I Spuls Menno A De Rie Pieter C Res Google Marcel B Teunissen Nataliya G Yeremenko Dominique L Baeten Saskia Chielie Phyllis I Spuls Menno A De Rie Pieter C Res Google Scholar Marcel B Teunissen Nataliya G Yeremenko Dominique L Baeten Saskia Chielie Phyllis I Spuls Menno A De Rie Pieter C Res PubMed Marcel B Teunissen Nataliya G Yeremenko Dominique L Baeten Saskia Chielie Phyllis I Spuls Menno A De Rie Pieter C Res Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.