Abstract
Asthma is a chronic inflammatory disorder of the airways resulting from an excessive Th2-dominated immune response to inhaled environmental antigens such as house dust mite (HDM). Recently though, individuals with severe asthma have been found to have high levels of IL-17A and IL-17F, suggesting that Th17 cytokines exacerbate allergic asthma. We have previously reported that in vivo blockade of IL-17A throughout the allergen exposure protocol attenuated the severe AHR observed in susceptible strains of mice (A/J) compared to mild responders (C3H) (Lajoie, Nature Immunol, 2010).
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