Abstract
Sepsis is a systemic inflammatory response resulting from the inability of the host to contain the infection locally. We previously demonstrated that during severe sepsis there is a marked failure of neutrophil migration to the infection site, which contributes to dissemination of infection, resulting in high mortality. IL-17 plays an important role in neutrophil recruitment. Herein, we investigated the role of IL-17 receptor signaling in polymicrobial sepsis induced by cecal ligation and puncture (CLP).
Highlights
Many authors have written about the need to treat patients closer to their beds, in order to observe them more as distinct people
We found that CCR2–/– mice subjected to severe sepsis by cecal ligation and puncture (CLP) exhibited reduced neutrophil infiltration in the heart, lung and kidney and an enhanced survival rate when compared with WT mice subjected to severe sepsis
Our findings demonstrated that Toll-like receptors (TLRs) activation induced the CCR2 expression and CCL2 responsiveness in human and murine neutrophils, and this expression profile in neutrophils is involved in the detrimental infiltration of these cells in distant tissues during server sepsis
Summary
Many authors have written about the need to treat patients closer to their beds, in order to observe them more as distinct people. Aortic dissection and aneurysm groups were analyzed against each other; and AAD patients were compared with paired matched CABG brackets for morbidity (postoperative complications and ICU and hospital lengths of stay) and 1-month and 6-month mortality. The incidence of VAP is high, varying between 6% and 52%, depending on the studied population, on the type of UTI and on the type of diagnosis technique used; in spite of being an extremely important infection, it is one of the most difficult diagnoses in critically ill patients. The objective of the present study was to assess the effectiveness of a daily MDR to improve compliance with the VAP bundle recommendations and other beneficial prophylactic measures in a high-volume critical care unit. Objective To verify the validity of the ADHERE CART method to stratify the risk of inhospital mortality of patients admitted with ADHF in a high-complexity Brazilian hospital
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