Abstract
Background: Earlier studies have shown that interlukin-10 (IL-10) -1082 A>G gene polymorphism is implicated in susceptibility to pulmonary tuberculosis (PTB), but their results are inconsistent and inconclusive. In the present study, a meta-analysis was performed to analyze the potential association between IL-10 -1082 A>G gene polymorphism and PTB susceptibility.Methods: A quantitative synthesis was done using PubMed (Medline), EMBASE, and Google Scholar web databases search and meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models.Results: A total of 22 eligible studies comprising 4956 PTB cases and 6428 healthy controls were included in the analysis. We did not observe any increased or decreased risk of PTB in allelic contrast (G vs. A: P=0.985; OR = 1.001, 95% CI = 0.863–1.162), homozygous (GG vs. AA: P=0.889; OR = 1.029, 95% CI = 0.692–1.529), heterozygous (GA vs. AA: P=0.244; OR = 0.906, 95% CI = 0.767–1.070), dominant (GG + AG vs. AA: P=0.357; OR = 1.196, 95% CI = 0.817–1.752), and recessive (GG vs. AA + AG: P=0.364; OR = 0.921, 95% CI = 0.771–1.100) genetic models. Likewise, no association of IL-10 -1082 A>G polymorphism with PTB risk was observed in Asian and African population for all the genetic models. Interestingly, the dominant model (GG + AG vs. AA: P=0.004; OR = 1.694, 95% CI = 1.183–2.425) demonstrated increased risk of PTB in Caucasian population.Conclusions: This meta-analysis concludes that IL-10 -1082 A>G gene polymorphism is not significantly associated with overall, Asian and African population. However, this polymorphism is associated with Caucasian population.
Highlights
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis or M. tb) is mainly a disease of the lungs mostly of pulmonary type tuberculosis (PTB), which can be spread to others by coughing and breathing
We found no association with pulmonary tuberculosis (PTB) risk in allele model (G vs. A: P=0.165; odds ratio (OR) = 1.300, 95% confidence interval (CI) = 0.898–1.883), homozygous model (GG vs. AA: P=0.569; OR = 1.407, 95% confidence intervals (95% CIs) = 0.434–4.562), heterozygous model (GA vs. AA: P=0.128; OR = 1.101, 95% CI = 0.973–1.246), dominant model (GG + AG vs. AA: P=0.438; OR = 1.614, 95% CI = 0.482–5.412), and recessive model (GG vs. AA + AG: P=0.244; OR = 1.240, 95% CI = 0.863–1.783) genetic models (Figure 6)
We found that there was no association between IL-10 -1082 A>G polymorphism and PTB susceptibility under any genetic models in overall analysis
Summary
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis or M. tb) is mainly a disease of the lungs mostly of pulmonary type tuberculosis (PTB), which can be spread to others by coughing and breathing. Remaining 5–15% of the infected individuals develop active disease later in life [2] This suggests that besides Mycobacteria itself, the host genetic factors may regulate the differences in host susceptibility to TB [3]. A meta-analysis was performed to analyze the potential association between IL-10 -1082 A>G gene polymorphism and PTB susceptibility. No association of IL-10 -1082 A>G polymorphism with PTB risk was observed in Asian and African population for all the genetic models. Conclusions: This meta-analysis concludes that IL-10 -1082 A>G gene polymorphism is not significantly associated with overall, Asian and African population. This polymorphism is associated with Caucasian population
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