Abstract
Selective degeneration of murine hippocampal granule cells was induced in 1‐month old BalbC mice by administration of trimethyltin (TMT) (2.5 mg/kg b.w.). Granule cell death bore the apoptotic features. We detected chromatin condensation, oligonucleosomal DNA fragmentation and caspase‐3 activation. Ribonuclease protection assay showed concomitant increase of interleukin‐1beta (IL‐1beta) and IL‐1 receptor antagonist (IL‐1ra) mRNA in the hippocampus. Moreover, an induction of IL‐1beta immunoreactivity was detected in reactive microglia in the area of neurodegeneration. Western blot showed the intensified synthesis of IL‐1ra in the dentate tissue. Temporal and spatial relation between apoptosis and expression of IL‐1 family proteins suggests the double role of these cytokines. Whereas IL‐1beta is probably engaged in neuronal apoptosis, IL‐1ra is involved in protection of spared granule cells.
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