IJCM_120A: Factors associated with neonatal sepsis in tertiary care hospitals of Mangalore: A retrospective study

Abstract

Background: Neonatal sepsis remains a significant cause of morbidity and mortality globally, particularly in developing countries like India. Early and late onset sepsis present unique challenges in diagnosis and management, with maternal and neonatal factors playing crucial roles in the manifestation of the condition. Methodology: Data were collected from tertiary care hospitals affiliated with Kasturba Medical College, Mangaluru. A structured proforma was used to gather information on maternal factors, birth history, neonatal conditions, and complications. Statistical analysis was performed using Chi- square test and student’s ‘t’ test. Results: Out of 132 cases, 50.75% were early onset sepsis (EOS) and 49.25% were late onset sepsis (LOS). Blood culture reports were positive in 46.1% cases. Maternal comorbidities included gestational diabetes mellitus (GDM), antepartum hemorrhage (APH), and pregnancy-induced hypertension (PIH). Neonatal comorbidities such as convulsions, congenital malformations, neonatal jaundice, preterm birth, and low birth weight were observed. Positive blood culture reports correlated with low birth weight and preterm births. Staphylococcus aureus was the most common organism, followed by Citrobacter Spp., Enterobacter Spp., and Pseudomonas aeruginosa. Sensitivity analysis revealed varying degrees of susceptibility to different antibiotics. Conclusion: Maternal factors like GDM, APH, and PIH showed no significant correlation with neonatal sepsis, whereas neonatal factors such as low birth weight and preterm birth were associated with an increased risk. Consanguinity also emerged as a potential risk factor. Staphylococcus aureus was the predominant causative organism, with varying antibiotic sensitivities. This study underscores the importance of understanding maternal and neonatal factors in the prevention and management of neonatal sepsis.