II型高リポ蛋白血症患者におけるProbucol(500mg 1日)投与の影響

Abstract

The effects of probucol on serum lipids, lipoprotein lipids, serum α-tocopherol and Co-Q10 were studied in 28 patients with type II hyperlipo-proteinemia.The patients received 2×250mg of probucol per day for 16 weeks.Total cholesterol, triglyceride and phospholipid were significantly reduced with probucol (20%, 17%, 18% respectively). LDL and HDL cholesterol were also reduced significantly (14%, 10% respectively), but atherogenic index (VLDL+LDL-Ch/HDL-Ch) was not significantly changed. The extent of the fall in total cholesterol was directly proportional to the pre-treatment total cholesterol level, the higher this level the greater the decrement. HDL-cholesterol fell by 46% in patients whose pre-treatment HDL-cholesterol levels were over 50mg/dl, but did not fall in patients whose pretreatment levels were under 40mg/dl.There was no significant change in serum α-tocopherol-concentration.Serum Coenzyme Q10 concentration were significantly reduced from 1, 765±308μg/ml to 1, 109±153μg/ml. Generally the drug was well accepted and free of significant toxic effects.These results suggested that probucol in a dose of 500mg/day appeared to be useful for the treatment in patients with type II hyperlipoproteinemia.