Abstract
Evaluations were made of the post-surgical prognosis of 17 dogs diagnosed as cases of grade II mast cell tumor (MCT). During the study period (median follow-up time: 273 days), 3 dogs died of MCT with local recurrence, one developed distant recurrence at a different cutaneous location (surviving still), and one died of an unrelated cause. In 14 dogs (82.4%), no recurrence was confirmed at primary sites, suggesting effective local control. Prognosis was related to clinical stage at the time of surgery. Dogs in stage I either survived or remained disease free significantly longer (P<0.05) than dogs in stages II and III. Numbers of argyrophilic nucleolar organizer regions (AgNOR) are associated with recurrence and MCTs with higher AgNOR counts (≥2.00/cell) indicated significantly shorter (P<0.05) disease-free intervals. These results suggest that the prognosis for grade II MCTs in clinical stage I is good and that AgNOR may be useful as a prognostic indicator in grade II MCTs.-Key
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