Abstract
Of the patients who had undergone colonic operation, the postoperatively administered as the prophylaxis for the infection was studied. They were prepared with kanamycin orally and postoperatively tobramycin was intramuscularly administered.The over-all incidence of infection after colonic surgery was 13.9 % (wound infectin 11.1%, bacteremia 1.4%), being significantly higher than that of 0 % after other digestive tract surgery (p<0.05). The wound infection rate in contaminated cases was 60.0% and in clean-contaminated cases 7.5 %.In all cases of wound infection, both anaerobic and aerobic bacteria were revealed. Main aerobic bacteria were Gram-positive rods sensitive to aminoglycosides, and main anaerobic bacteria were resistant to aminoglycosides.These results suggest the efficacy of the combined administration of aminoglycosides and other drugs effective to anaerobic bacteria.
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