Abstract
<h2>Abstract</h2> The non-steroidal anti-oestrogen tamoxifen has a number of gynaecological side-effects. Apart from an increased risk of endometrial carcinoma, recently ovarian cyst formation during tamoxifen has been observed. This induces the problem of whether or not intervention for these cysts is required. In a cross-sectional study of breast cancer patients receiving tamoxifen, patients only developed ovarian cysts if ovaries responded to tamoxifen, as shown by oestradiol production. Ovarian cysts were not likely to develop in women with amenorrhoea > 1 year or following high-dose chemotherapy.
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