Abstract

Hypoxia-inducible factor-1 （H/F-1）, as a nuclear transcription regulator of the hypoxic response, is up-regulated during hypoxia, and it regulates a series of downstream target gene expression, such as vascular endothelial growth factor, glucose transporter and erythropoietin through binding with hypoxia response element. It plays important roles in angiogenesis, anerobic metabolism, cell survival, proliferation, migration, and differentiation. This article reviews the structure, function and activity regulation of HIF-1 and its roles in acute ischemic brain injury. Key words: Hypoxia-inducible factor 1 ; Brain ischemia; Brain injury

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