IgM nephropathy on the background of Hodgkin's lymphoma: clinical case and literature review

Abstract

IgM nephropathy, although a rare and controversial disease, attracts the attention of both morphologists and clinicians. The issues of etiopathogenesis, epidemiology and treatment of this pathology are currently insufficiently studied. A variety of morphological manifestations under light microscopy make immunofluorescence examination crucial for diagnosis. Although IgM nephropathy shares clinical and morphological features with minimal change disease and focal segmental glomerulosclerosis, it has its own characteristics that not all scientists recognize as sufficient to classify it as a separate nosological form. It is necessary to coordinate morphological criteria for the diagnosis of IgM nephropathy. Clarifying the pathogenetic mechanisms of the development of this disease will help determine the place of IgM nephropathy among primary glomerulopathies. A rare case of association of IgM nephropathy and Hodgkin's lymphoma is presented.