Abstract
IN mice, paternal tissue grafts generally survive longer in the mother with each succeeding pregnancy1. Similar findings have been reported for rats, rabbits and humans2. Paternal tumours also survive longer in pregnant mice3. However, mating across strain does include cellular immunity directed against paternal antigens, measured by graft versus host activity4 and in vitro killing of hybrid foetal cells3 by maternal lymphocytes. Thus the survival of experimental allografts1,3 and of the natural foetal “allograft” in the face of maternal cellular immunity may depend on immunological enhancement, that is, the protection of foreign grafts by specific antibody which blocks cellular immune rejection3,5.
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