IGly-IDN: Identifying Lysine Glycation Sites in Proteins Based on Improved DenseNet.

Abstract

Lysine glycation is one of the most significant protein post-translational modifications, which changes the properties of the proteins and causes them to be dysfunctional. Accurately identifying glycation sites helps to understand the biological function and potential mechanism of glycation in disease treatments. Nonetheless, the experimental methods are ordinarily inefficient and costly, so effective computational methods need to be developed. In this study, we proposed the new model called iGly-IDN based on the improved densely connected convolutional networks (DenseNet). First, one hot encoding was adopted to obtain the original feature maps. Afterward, the improved DenseNet was adopted to capture feature information with the importance degrees during the feature learning. According to the experimental results, Acc reaches 66%, and Mathews correlation coefficient reaches 0.33 on the independent testing data set, which indicates that the iGly-IDN can provide more effective glycation site identification than the current predictors.