Abstract
The level of serum IgE and IgG4 antibodies, which are specific to dermatophagoides farinae, were estimated by indirect enzymelinked immunosorbent assay during immunotherapy with patients effected by house-dust. We studied 17 patients who had begun house-dust immunotherapy, and every month we measured the IgE and IgG4 antibody titers in their serum.The IgG4 a ntibody titers were increased by immunotherapy (64.7%) and began to rise 24 weeks later. However, this was not correlated with nasal clinical symptom improvement.In many observed cases, the IgG4 antibody titers were high and the IgE antibody titers were low, this often appeared during immunotherapy (41.2%).Whether specific IgG4 did act as “blocking antibodies” during immunotherapy in nasal allergy patients, remained uncertain.
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