IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution.

Abstract

Retraction1 November 2002free access IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution T.S. Ramalingam T.S. Ramalingam Search for more papers by this author Scott A. Detmer Scott A. Detmer Search for more papers by this author W.Lance Martin W.Lance Martin Search for more papers by this author Pamela J. Bjorkman Pamela J. Bjorkman Search for more papers by this author T.S. Ramalingam T.S. Ramalingam Search for more papers by this author Scott A. Detmer Scott A. Detmer Search for more papers by this author W.Lance Martin W.Lance Martin Search for more papers by this author Pamela J. Bjorkman Pamela J. Bjorkman Search for more papers by this author Author Information T.S. Ramalingam, Scott A. Detmer, W.Lance Martin and Pamela J. Bjorkman The EMBO Journal (2002)21:5953-5953https://doi.org/10.1093/emboj/cdf617 This article retracts the following: IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution15 February 2002 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The EMBO Journal, 21, 590–601, 2002 We wish to inform you that we have been unable to reproduce a result described in the above paper. Specifically, we do not observe ligand-induced redistribution of FcRn expressed in MDCK cells when we compare confocal images of the distribution of FcRn–GFP in cells incubated in the presence or absence of IgG ligand (D.B.Tesar, N.E.Tiangco, S.A.Detmer and P.J.Bjorkman, unpublished results). We are in the process of repeating the other experiments described in the paper and cannot yet comment on their reproducibility, but as ligand-induced redistribution was the focus of the paper and this result cannot be replicated, we wish to retract the paper now. We deeply regret any inconvenience our publication of this result has caused for others. The first author of this paper (T.S.R.), who performed most of the experimental procedures and data analysis, has chosen not to be associated with this retraction. Previous ArticleNext Article Read MoreAbout the coverClose modalView large imageVolume 21,Issue 21,November 1, 2002Cover. Sectioned schematic view of an icosahedral pyruvate dehydrogenase complex based on electron cryo-microscopic analysis of an E1E2 sub-complex from B.stearothermophilus. Three of the 60 E2 molecules (colored red, green and yellow) are highlighted. The movement of the swinging E2 lipoyl domain in the annular region between the inner core (cyan) of E2 molecules and the outer shell of E1 molecules (purple) is proposed to be a critical feature underlying active site coupling in the complex. Jacqueline Milne and Sriram Subramaniam work at the National Cancer Institute, NIH in Bethesda, MD, USA ( http://hrem.nci.nih.gov). The artist is Donald Bliss at the Medical Arts and Photography Branch at NIH. For further details, see Milne et al., pp. 5587--5598. Volume 21Issue 211 November 2002In this issue RelatedDetailsLoading ...