Abstract
Ligation of Fc-γ receptors for IgG (FcγR) can trigger potent effector cell responses. Genetic polymorphisms of these receptors modify IgG binding, and influence internalization of immune complexes. In patients with infectious or autoimmune diseases, skewing towards low-binding FcγR alleles has been demonstrated. The objective of this study was to investigate the influence of FcγR polymorphism on leukocyte activation.
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