Abstract
A total of 60 sera from patients with cervical cancer, 60 sera from matched controls, and 22 sera from 13 patients with recent herpes genitalis were examined by the indirect fluorescent antibody method for the presence of IgG-, IgA- and IgM-antibodies to herpes simplex virus (HSV) type 2. IgG-antibody titres in the patients with cervical cancer were significantly higher than those found in the control group, while IgA- and IgM-antibodies were normal. IgG-, IgA- and IgM-antibodies were found to be elevated in patients with frequent recurrent HSV type 2 infections. The elevation of a single class of immunoglobulin to HSV type 2 infection is serologically unusual and distinguish the patients with cervical cancer not only from normal controls but also from patients with frequent recurrent or chronic genital herpes.
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