Abstract
Insulin-like growth factors-I and -II (IGF-I and IGF-II) are peptide growth factors closely related in sequence to insulin (1,2). In the nervous system, the IGFs, IGF receptors, and IGF binding proteins (IGFBPS) are widely expressed and promote proliferation, survival, and differentiation of neuronal and nonneuronal cells. In addition, high levels of IGFs and IGFBPs are found in a variety of nervous system tissues during development. Because of their potent survival and differentiation activities, the IGFs are currently being tested as therapeutics for a variety of neuronal pathologies, including various neuropathies, motor neuron disease, and physical or hypoxic—ischemic insults. The physiological effects of the IGFs in the nervous system are thought to be mediated by the IGF-I receptor, while the IGF-II receptor, in conjunction with the IGFBPs, regulates IGF bioavailability.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
