IGFBP-2 enhances insulin signalling and glucose uptake in human skeletal myotubes

Abstract

(BPP), peptide-YY and desire-to-eat were greater (P < 0.05), while amount eaten was less (P < 0.05), at week-4 and week-12 compared with baseline. Conclusions: 4-day of 30% energy-restriction modestly affects the responses to intraduodenal lipid in health and obesity, but not energy intake, while 12-week of energy-restriction, associated with weight-loss, enhances lipid-induced BPP and peptide-YY, and reduces food intake (despite increased desire-to-eat), suggesting that energyrestriction increases gastrointestinal ‘‘sensitivity’’ to lipid.