Abstract
BackgroundInsulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF2BP3 expression has not been fully settled in vascular lesions.MethodsWe evaluated the expression of IGF2BP3 in malignant (angiosarcoma and epithelioid hemangioendothelioma [EHE]) and benign (hemangioma, granulation tissue cappilaries, and pyogenic granuloma) vascular lesions using immunohistochemistry. IGF2BP3 expression was scored as negative (0% of endothelial/neoplastic cells), equivocal (1–25%), or positive (> 26%).ResultsEight of 30 (26.7%) cases of angiosarcoma and two of five (40%) cases of epithelioid hemangioendothelioma were positive for IGF2BP3. In contrast, hemangiomas (10 cases) and granulation tissue capillaries (12 cases) were all negative for IGF2BP3, and some cases of pyogenic granuloma (six of 14 cases) was scored as equivocal. In angiosarcoma, IGF2BP3 expression was independent of age, gender, location, morphological pattern, prognosis, presence of metastatic foci, and PD-L1 expression.ConclusionsIGF2BP3 is a useful marker to distinguish between malignant and benign vascular lesions.
Highlights
Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3) is an oncofetal protein that is highly expressed in fetal tissue and gonads but is rarely found in other adult benign tissues [1]
There was no difference in clinical parameters between IGF2BP3-positive and – equivocal /-negative cases (Table 2)
We assessed the association between IGF2BP3 expression and PD-L1 expression, which is a positive prognostic marker for angiosarcoma [13]
Summary
IGF2BP3 is an oncofetal protein that is highly expressed in fetal tissue and gonads but is rarely found in other adult benign tissues [1]. Leiomyosarcoma and chondrosarcoma express IGF2BP3, whereas their benign counterparts, leiomyoma and chondroma, are negative [3, 5]. Angiosarcoma is a malignant tumor of vascular endothelial origin and is associated with poor prognosis [9]. Surgery is the most common approach to treat angiosarcoma, and achieving surgically negative margins improves prognosis [11, 12]. Accurate evaluation of surgical margins is essential for management of cutaneous angiosarcoma patients. Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF2BP3 expression has not been fully settled in vascular lesions
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