IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer.

Chia-Hsuan Chou,Min-Chien Hsin,Chien-Yuan Chang,Chiao-Wen Lin,Shun-Fa Yang,Hsueh-Ju Lu,Mu-Kuan Chen,Hsien-Cheng Huang,Chia-Ming Yeh

doi:10.3390/ijms21165662

Abstract

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is associated with insulin resistance, lipid metabolism, and tumorigenesis. However, the association between the IGF2BP2 polymorphism and oral cancer risk remains unclear. We recruited 1349 male patients with oral cancer and 1198 cancer-free controls. Three single nucleotide polymorphisms IGF2BP2 rs11705701, rs4402960, and rs1470579 were assessed using real-time polymerase chain reaction. The results indicate that the male patients with oral cancer and with the rs11705701 GA+AA, rs4402960 GT+TT, and rs1470579 AC+CC genotypes had increased risk of advanced clinical stage, larger tumor, and progression of lymph node metastasis compared with those with wild-type IGF2BP2. Moreover, according to The Cancer Genome Atlas dataset, high expression of the IGF2BP2 gene is associated with poor survival in patients with head and neck squamous cell carcinoma. In conclusion, our results suggest that IGF2BP2 polymorphisms are associated with less favorable oral cancer clinical characteristics.

Highlights

Oral cancer is the sixth most common malignancy worldwide, and oral squamous cell carcinoma (OSCC) is most the prevalent type [1]
Some studies have reported that the single nucleotide polymorphism (SNP) of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is associated with diabetes and non-small-cell lung cancer (NSCLC)
After adjustment for several variables, no significant difference in distributions of IGF2BP2 rs11705701, rs4402960, and rs1470579 was observed between the case and control groups (Table 2)

Summary

Introduction

Oral cancer is the sixth most common malignancy worldwide, and oral squamous cell carcinoma (OSCC) is most the prevalent type [1]. The unchanging survival rate in patients with OSCC underscores the need for better prognostic tools, such as the addition of “Depth of invasion”. Some studies have reported that the single nucleotide polymorphism (SNP) of IGF2BP2 is associated with diabetes and non-small-cell lung cancer (NSCLC). Rao et al [10] and Wu et al [11] demonstrated that the IGF2BP2 polymorphism is associated with type 2 diabetes (T2D) and obesity. Chen et al suggested that the IGF2BP2 rs4402960 polymorphism T allele may be a protective factor for decreased susceptibility to NSCLC among women [13]. Tang et al found that the IGF2BP2 rs1470579 variant is a protective factor against esophagogastric junction adenocarcinoma [14]

Methods

Results

Discussion

Conclusion