Abstract
IGF signaling in muscle degenerative diseases
Highlights
Conserved signaling pathways and transcription factors that sense physiological and environmental states regulate aging processes
The most prevalent form of muscular dystrophies is Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene
We reasoned that cellular stress responses would be the modulators of susceptibility because stress proteins and cellular calcium levels are elevated in the muscles of human DMD patients and mammalian models
Summary
Conserved signaling pathways and transcription factors that sense physiological and environmental states regulate aging processes. Our recent study (Oh, PNAS, 2013, 110: 19024) shows that lifespan-extending signaling pathways may provide opportunities for therapeutic interventions of muscle degenerative diseases. Dystrophin and its associated proteins and major signaling and cell death pathways are highly conserved from worms to humans.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.