Abstract
IGF signaling in muscle degenerative diseases
Highlights
Conserved signaling pathways and transcription factors that sense physiological and environmental states regulate aging processes
The most prevalent form of muscular dystrophies is Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene
We reasoned that cellular stress responses would be the modulators of susceptibility because stress proteins and cellular calcium levels are elevated in the muscles of human DMD patients and mammalian models
Summary
Conserved signaling pathways and transcription factors that sense physiological and environmental states regulate aging processes. Our recent study (Oh, PNAS, 2013, 110: 19024) shows that lifespan-extending signaling pathways may provide opportunities for therapeutic interventions of muscle degenerative diseases. Dystrophin and its associated proteins and major signaling and cell death pathways are highly conserved from worms to humans.
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