Abstract
OBJETIVO: Avaliar o efeito do tratamento com IGF-1 sobre o perfil metabólico e morfológico do músculo sóleo submetido à imobilização articular de tornozelo. MÉTODOS: Ratos Wistar foram divididos em 3 grupos (n=6): controle (C), imobilizado (I) e imobilizado tratado com IGF (I+IGF; 40mg/Kg) durante 7 dias. RESULTADOS: A imobilização reduziu o peso (34%), o conteúdo de glicogênio (31,6%) a área das fibras musculares (44%), e elevou na densidade do tecido conjuntivo (216%). Por outro lado, o IGF-1 aumentou o glicogênio em 234,6% quando comparado ao I, minimizou a redução de 33,7% na área das fibras musculares e aumentou de 76% no tecido conjuntivo comparado ao C (p<0,05). CONCLUSÕES: O tratamento com IGF demonstrou uma ação anti-catabólica, fato esse que pode favorecer uma recuperação mais rápida na fase pós-imobilização. Nivel de evidência: Nível II: estudo prospectivo comparativo.
Highlights
Several experimental models are proposed with the intention of identifying the events triggered by muscle disuse and generation of the precursor processes of atrophy, with denervation, tenotomy, prolonged bed rest, suspension of the animal’s hind limbs or unilateral immobilization of limbs by orthosis meriting special emphasis.[1]
A reduction of 44% (p
Our results demonstrated that IGF-1 can be used in the initial phase of muscle disuse, since it minimizes the reduction of muscle glycogen content, area of the fibers, and the increase of area density of the connective tissue
Summary
Several experimental models are proposed with the intention of identifying the events triggered by muscle disuse and generation of the precursor processes of atrophy, with denervation, tenotomy, prolonged bed rest, suspension of the animal’s hind limbs or unilateral immobilization of limbs by orthosis meriting special emphasis.[1]. In at least two models of disease in animal experiments, amyotrophic lateral sclerosis and Duchenne muscular dystrophy, local treatment with IGF proved to delay the onset and progression of the disease and to reduce its severity.[8] there are few studies demonstrating the effects of IGF-1 in the acute phase of immobilization. The hypothesis of this study was that treatment with IGF-1 minimizes the harmful effects promoted by soleus muscle immobilization. The objective of this study was to evaluate the action of IGF treatment on the soleus muscle in the condition of joint immobilization, under the aspects of weight, glycogen content, muscle fiber area and density of intramuscular connective tissue. All the authors declare that there is no potential conflict of interest referring to this article. 2- Universidade Federal de São Carlos, SP, Brazil. 3- Universidade Estácio de Sá, Belo Horizonte – MG, Brazil. Article received on 10/08/09, and aproved on 03/26/10 Acta Ortop Bras. Article received on 10/08/09, and aproved on 03/26/10 Acta Ortop Bras. 2011;19(3): 137-40
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