Abstract
Introduction Autism Spectrum Disorder (ASD) includes a set of disorders characterized by deficits in communication, social interactions and stereotypical behaviors. Recent studies suggest a higher frequency of atopic diseases (asthma, allergic rhinitis, food allergies...). The aim of our study was to assess IgE sensitization to the most frequent allergens in children with ASD. Methodes The study involved 30 children with ASD and 39 controls. The total IgE as well as the IgE specific to the food (FP2, FP5 and FP51) and respiratory (HP1 and GP1) allergen panels were determined in all children by chemiluminescence technique on the Immulite 2000Xpi. Results There was no significant difference between children with ASD and control in total IgE levels (high IgE level in 66.7% TSA vs 51.3%). Overall analysis of IgE sensitization to common allergens showed a higher frequency in ASD children (65.6% ASD versus 28.9% control, P = 0.002). Also, sensitization to house dust allergens (D1, D2 and I6) and to food allergens of FP5 panel (F1, F2, F4, F13 and F210) was more common in children with ASD (46.87% vs 21.05% and 37.5% vs. 13.16%, respectively, P Discussion Recent epidemiological studies have shown a strong statistical correlation between risk for ASD and either maternal or infantile atopic diseases, such as asthma, eczema, food allergies and food intolerance. One explanation for such high rates of allergic diseases in the ASD group could relate to immune sensitivity corresponding to intrinsic stress factors and/or psychosocial stress commonly found in children with ASD. In addition, some research has suggested that stress could aid in releasing neurogenic inflammatory agents, which is also identified in bronchial mucosa or immune cells, and conversely, that the immune system could also modulate the central nervous system function via various molecules, including cytokines. Conclusion Our study found an increased IgE sensitization to common respiratory and food allergens in ASD children.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
