IgE, IgG, TSLP, Il 25 and IL 33 in symptomatic and asymptomatic patients sensitized to shrimp allergens

Abstract

ABSTRACTBackground: Presence of IgG antibodies specific for shrimp allergens indicates a past exposure to shrimp proteins, but it is suspected that in the concentration of IgG specific for food allergens may affect the induction and maintenance of tolerance. Material and Methods: 40 patients with a positive skin prick test for shrimp allergens. The concentration of shrimp-specific IgE and IgG4 as well as TSLP, IL-25 and IL-33 in blood serum was assessed. Results: IgG and IgE level, as well as IL-25, IL-33 and TSLP concentration had no effect on the nature and severity of the clinical symptoms. There was no correlation between the concentrations of IL-25, IL-33 and TSLP and the age and sex of the participants. Conclusion: There was an absence of relationship between allergy symptoms and the concentration of sIgG, sIgE, TSLP, IL-25 and IL-33. In shellfish allergy, the role of IgG4 has not yet been elucidated.