IgE and IgG Antibodies to Staphylococcus aureus Solubilized Cell Wall Proteins and Teichoic Acid in Patients with the Hyper‐IgE Syndrome

Abstract

AbstractThe anti‐staphylococcal IgE and IgG antibody levels of patients with hyper‐IgE syndrome (HIE) were measured by microtiter solid phase radioimmunoassay (MSPRIA) and enzyme‐linked immunosorbent assay (ELISA) using solubilized cell wall proteins (SCWP) and teichoic acid extracted from Staphylococcus aureus.Using MSPRIA, specific IgE antibodies to SCWP were detected at significant levels in all 5 patients with HIE, but not in 23 patients with atopic allergy or Wiskott‐Aldrich syndrome with or without staphylococcal infections. IgG antibodies to SCWP and teichoic acid were lower in the patients with HIE than those in non‐allergic infectious controls. These findings suggest an abnormal immunologic response to Staphylococcus aureus in patients with HIE.