Abstract
The biological significance of IgA antibody to inhalant allergens in nasal fluid was studied. The concentration of IgA antibodies to house dust mite in the nasal fluids which were collected by suction from patients with mite allergy, was measured by a double antibody technique. As a result, allergen-binding activity of nasal fluid antibodies to mite was found to suffice the participation of the IgA antibody in the local immunity to mite which is inhaled and deposited on the surface of the nasal mucous membrane. However the severity of reaction from nasal provocation with mite extract was found to be independent of the concentration of antibodies in nasal fluid. The binding activity of nasal fluid IgA antibody did not increase after immunotherapy with mite and found to be independent of the structure of serum or nasal fluid IgA. Moreover, on the basis that the nasal fluid-serum ratio of IgA antibody was much greater than that of IgG or IgE antibody to mite, the local production of IgA antibody to mite was strongly suggested. The biological significance of IgA antibody to inhalant allergens in nasal fluid was studied. The concentration of IgA antibodies to house dust mite in the nasal fluids which were collected by suction from patients with mite allergy, was measured by a double antibody technique. As a result, allergen-binding activity of nasal fluid antibodies to mite was found to suffice the participation of the IgA antibody in the local immunity to mite which is inhaled and deposited on the surface of the nasal mucous membrane. However the severity of reaction from nasal provocation with mite extract was found to be independent of the concentration of antibodies in nasal fluid. The binding activity of nasal fluid IgA antibody did not increase after immunotherapy with mite and found to be independent of the structure of serum or nasal fluid IgA. Moreover, on the basis that the nasal fluid-serum ratio of IgA antibody was much greater than that of IgG or IgE antibody to mite, the local production of IgA antibody to mite was strongly suggested.
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