Abstract
e18553 Background: The B-cell receptor complex (BCRC) comprises an assembly of membrane-associated proteins in a lipid raft. Included in this complex is membrane Ig (mIg), which is associated with phosphotyrosine kinase signal transduction proteins CD79 a and b and spleen tyrosine kinase. The membrane B-cell receptors are constructed of homologues of their circulating immunoglobulin counterparts with an additional extracellular domain in proximity to the trans-membrane peptide. There are 8 specific sequences in the human genome for these domains: one each for mIgM, mIgG, mIgD, two variants for mIgE and three sequences for mIgA. We investigated whether these domains contain sequence homology to known proteins in order to gain insight into their function and evaluate their specificity. Methods: Using the Blast (Basic Local Alignment Search Tool) homology search engine we compared all 8 sequences to data in the human genome bank (UniProtKB/Swiss-Prot). In addition, specificity of sequences was confirmed by P...
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