Abstract
Primary cilia are present on most eukaryotic cells, where they function as sensory organelles to relay information from the external environment into the cell. Cilia are assembled by means of intraflagellar transport (IFT) — a process carried out by multimeric IFT particles and molecular motors. Finetti et al. now reveal an unexpected new role of IFT in cells lacking cilia, by showing that IFT is part of the membrane trafficking pathway that orchestrates signalling at the immune synapse — a platform that can integrate, fine-tune and terminate signalling.
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