Abstract
The present work studied the effect of aqueous extract from Feijoa leaves on thyroid function of rats with experimental hypothyroidism. Healthy albino rats weighing between 120 gand 150 gwere used. The animals were randomly allotted into four groups, each containing eight rats respectively. Three of the groups (II, III and IV), induced with hypothyroidism, were treated by 0.05 % solution of thiamazole with drinking water for 30 days. Control (vehicle) rats were given normal saline. After 13 days hypothyroid groups (III and IV) of rats were treated with aqueous extract from Feijoa leaves at a dose 1.0 ml/100 g of body weight and with Iodomarin 200 (reference drug) at a dose 12 µg/kg daily orally for 21 days. Results obtained from the study showed that the introduction of thiamazole leads to functional changes in the thyroid gland in rats, accompanied by decreasing sings of rectal temperature and level of thyroid hormones. It was found, that treatment with AEFL normalizes serum thyroid hormone levels, increases rectal temperature and reduces the thyroid mass. The investigated extract can be attributed to the regulators of the thyroid hypofunction and is promising for further study of its effectiveness as a thyroid-stimulating agent.
Highlights
Increased interest in the problem of thyroid pathology in recent years is due to its distribution among the population, as well as high frequency of temporary and permanent disability, which determines the social significance of diseases [1, 2]
The increase in the frequency of thyroid pathology is due to the influence of adverse environmental factors, the deterioration of the overall ecological situation, which contribute to reducing the immunological defense of the body, as well as defective food and stress factors [2, 4]
The results of this study indicate the effectiveness of AEFL in thyroid hypofunction
Summary
Increased interest in the problem of thyroid pathology in recent years is due to its distribution among the population, as well as high frequency of temporary and permanent disability, which determines the social significance of diseases [1, 2]. According to some epidemiological studies in some population groups, the prevalence of hypothyroidism reaches 10–12 % and is constantly increasing. In adults, it is in the range of 1.4 to 2 % for women and 0.2 % for men. Among the surveyed (without thyroid diseases in past medical history), the percentage of patients with hypothyroidism reaches 6 % among women and 2.5 % in men. The incidence of hypothyroidism in children is 1: 3000–4000 [1]
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