Abstract
Intramuscular administration of the minimum effective doses (MED) of the central analgesics fentanyl and Analgin [translator’s note: metamizole], the NMDA receptor polyamine site agonist spermine, and IEM-1460, an AMPA receptor blocker and agonist of the NMDA receptor polyamine site, induced maximal analgesic effects in the tailflick test in rats. Combined intramuscular administration of Analgin and IEM-1460 and spermine at threshold doses inactive when given alone (1/5 MED) allowed the MED of Analgin to be reduced by a factor of 120 when given in combination with IEM-1460 and by a factor of 10 when given in combination with spermine. Combined intramuscular administration of fentanyl with IEM-1460 and spermine at these threshold doses decreased the MED of fentanyl by a factor of 150 when used with IEM-1460 and a factor of 15 when used with spermine.
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