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Abstract
The domestic dog (Canis lupus familiaris) is indisputably one of man's best friends. It is also a fundamental model for many heritable human diseases. Here, we present iDog (http://bigd.big.ac.cn/idog), the first integrated resource dedicated to domestic dogs and wild canids. It incorporates a variety of omics data, including genome sequences assemblies for dhole and wolf, genomic variations extracted from hundreds of dog/wolf whole genomes, phenotype/disease traits curated from dog research communities and public resources, gene expression profiles derived from published RNA-Seq data, gene ontology for functional annotation, homolog gene information for multiple organisms and disease-related literature. Additionally, iDog integrates sequence alignment tools for data analyses and a genome browser for data visualization. iDog will not only benefit the global dog research community, but also provide access to a user-friendly consolidation of dog information to a large number of dog enthusiasts.
Highlights
The domestic dog (Canis lupus familiaris) and humans have enjoyed one of the oldest comraderies in history [1], together concurring several biotic and abiotic odds to settle in all corners world
To further cement their participation in human life, the domestic dog has emerged as a premier model for heritable human diseases, facilitating the identification and study of numerous disease loci [13,14,15,16], those associated with cancers
Canine Inherited Disorders Database (CIDD) provides detailed descriptive information of canine inherited disorders in various breeds, while Online Mendelian Inheritance in Animals (OMIA) curates genes and variants information related to dog diseases from published papers
Summary
The domestic dog (Canis lupus familiaris) and humans have enjoyed one of the oldest comraderies in history [1], together concurring several biotic and abiotic odds to settle in all corners world. CIDD provides detailed descriptive information of canine inherited disorders in various breeds, while OMIA curates genes and variants information related to dog diseases from published papers. These two databases have different disease description formats and disease-naming methods, and are not linked to each other. D794 Nucleic Acids Research, 2019, Vol 47, Database issue to provide convenience in searching for a particular dog disease and obtaining its detailed description and associated genes. IDog includes two recently released genomes [22], genomic variations, phenotype/disease traits, gene expression profiles, functional annotations, gene homologs and informative literature. Gene ontology (GO) Molecular function Genes Annotations Biological process Genes Annotations Cellular component Genes Annotations
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