Abstract
A case of severe idiopathic orthostatic hypotension is described. The patient had only temporary relief of symptoms with conventional therapy of hydroxyamphetamine (Paredrine) and fludrocortisone (Florinef). Subsequently, while closely observed in the hospital, his condition responded satisfactorily to a new form of therapy: the combined administration of hydroxyamphetamine with a monamine oxidase inhibitor, tranylcypromine (Parnate). The pathophysiology of idiopathic orthostatic hypotension is reviewed and the rationale of this new form of therapy is discussed.
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