Abstract
ABSTRACTIntroduction:Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern.Case presentation:The authors present the case of a 44-year-old Hispanic smoker female with hypertension and peripheral arterial disease who presented nephrotic syndrome for 2 weeks. The patient was diagnosed with ING by percutaneous renal biopsy results, which showed global nodular mesangial matrix expansion, with linear staining accentuation of glomerular and tubular basement membrane for Immunoglobulin G (IgG) and albumin on immunofluorescence.Conclusions:ING is a rare disease with a poor renal prognosis and wide diagnostic approach; we highlight the importance of analyzing every piece of detail together to reach a definitive diagnosis.
Highlights
Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern
Relevant laboratory findings were hemoglobin of 7 gr/dL, creatinine of 4 mg/dL, albumin 3.5 gr/dL, sodium 128 mEq/L, potassium 4.5 mEq/L, hypercholesterolemia (244 mg/dL, reference value >200 mg/dL), and proteinuria of 7.4 grams in 24 hours
Percutaneous renal biopsy (Figure 1) was performed demonstrating 27 glomeruli, of which 23 were globally sclerosed, with global nodular mesangial matrix expansion, which stained blue with the Masson trichrome, and was Congo Red negative by light microscopy (LM)
Summary
Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern. Ela foi diagnosticada com GNI por biópsia renal percutânea, que mostrou expansão generalizada da matriz mesangial nodular, com acentuação de coloração linear na membrana basal glomerular e tubular para imunoglobulina G (IgG) e albumina à imunofluorescência. Idiopathic nodular glomerulosclerosis (ING) is a rare condition that has vasculopathic glomerular histological pattern, which represents 0.45% of all the biopsies in large series[1].
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