Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria

Tajamul H Shah,Sonaullah Shah,Umar H Khan,Mufti S,Parvaiz A Koul,Fayaz A Sofi,Ajaz N Koul,Rafi Ahmed Jan

doi:10.4236/ojneph.2013.32017

Tajamul H Shah, Sonaullah Shah + Show 6 more

Open Access

https://doi.org/10.4236/ojneph.2013.32017

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Journal: Open Journal of Nephrology	Publication Date: Jan 1, 2013
Citations: 16	License type: CC BY 4.0

Abstract

Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count (eosinophilia) along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1-4], with no obvious cause for eosinophilia. The onset of symptoms is insidious in most of the cases and eosinophilia is detected incidentally. However, in others, the initial manifestations are severe and life-threatening due to the rapid evolution of cardiac or neurologic complications [5]. Renal involvement is rarely reported [6] in IHES. Herein we reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy.

Highlights

A 50-year old male presented with a 3-week history of a non-productive cough, associated with intermittent low grade fever, periorbital puffiness and lower extremity edema
Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1,2,3,4], with no obvious cause for eosinophilia
We reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy

Summary

Introduction

A 50-year old male presented with a 3-week history of a non-productive cough, associated with intermittent low grade fever, periorbital puffiness and lower extremity edema. Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count (eosinophilia) along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1,2,3,4], with no obvious cause for eosinophilia. Renal involvement is rarely reported [6] in IHES. We reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy.

Results

Conclusion