Abstract
Angioedema is a localized and self-limited swelling of the deep layers, which can be life-threatening when it occurs in the larynx. It is often located on the eyelids or lips, where the connective tissue is looser and is not position‑dependent. The frequency and severity are variable. It is often associated with urticaria or other signs of allergy, but can also be an isolated manifestation – a form in which the mechanism of production is less understood, that sometimes makes the treatment a challenge. An appropriate clinical approach and the appropriate treatment are essential because the prognosis and treatment of bradykinin-mediated and mast cell-mediated angioedema (by IgE-mediated or non-IgE-mediated mechanism) differ, with a 45-fold higher risk of bradykinin‑mediated angioedema than for mast cell-mediated angioedema.
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