Abstract
Background: Visceral adipose tissue (VAT) displays metabolic fingerprints that differ according to the individual’s BMI and glycemic status. Incretin hormones, GLP-1 and GIP, known to play an important role in stimulating glucose-dependent insulin secretion, have also been hypothesised to influence glucose metabolism by acting in other peripheral tissues. Since twincretin hormone analogue drugs are emerging therapies for type 2 diabetes (T2D) and obesity, its potential role in adipose tissue metabolism merits further investigation.
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