IDF21-0354 Glucoraphanin has the therapeutic potential of resolving hepatic steatosis in a murine model of diet-induced obesity

Abstract

Background: Glucoraphanin (GR) is a natural glucosinolate abundantly found in broccoli sprouts. GR is converted to sulforaphane by myrosinase enzyme and the metabolite is a potent activator of a nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Activation of Nrf2 induces antioxidant and detoxication-related genes, thus leading to cellular protection against oxidative stress. We have demonstrated that GR has preventive effects on impairment of glucose homeostasis in diet-induced obese (DIO) mice via an increment in energy expenditure, shifting macrophage polarization in liver and adipose tissue, and changing microbiota characteristics.