Abstract
Interaction between two antagonistic mediators, acetylcholine and serotonin, was investigated by a kinetic method on the isolated ventricle ofMytilus grayanus andNeptunea sp. When both substances act simultaneously on the myocardium, they behave as antagonists of competitive and mixed types. Similar results were obtained on the isolated frog ventricle during simultaneous action of acetylcholine and adrenalin on the myocardium. Nonspecific factors inducing reversible denaturation of proteins (brief exposure to a high temperature or to 15% urea) led to temporary blocking of sensitivity to both mediators. After their action the sensitivity of the frog heart muscle to acetylcholine and adrenalin is gradually restored, and the recovery curves for the two mediators coincide. The identity of the receptor proteins for the antagonistic mediators is discussed.
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