Abstract
Identifying the Role of GluN2A in Cerebral Ischemia.
Highlights
The activity of the NMDA receptor (NMDAR), which is a glutamate-gated ion channel, is a key factor influencing the neuronal damage following cerebral ischemia
Understanding the role of the GluN1/2A/2B receptor in cerebral ischemia may be critical for identifying the specific role of the GluN2A subunit, which may mediate pro-survival effects following cerebral ischemia
Previous studies of cerebral ischemia have ignored the influence of the triheteromeric GluN1/2A/2B receptor despite the fact that this receptor accounts for a large proportion of the NMDARs in the adult forebrain
Summary
The activity of the NMDA receptor (NMDAR), which is a glutamate-gated ion channel, is a key factor influencing the neuronal damage following cerebral ischemia. GluN1, GluN2A, and GluN2B are the primary NMDAR subunits in the adult forebrain. The functional properties of these NMDARs depend mainly on the GluN2 subunits, and many studies primarily classify NMDARs as GluN2A- and GluN2B-containing NMDARs. given the influence of the triheteromeric GluN1/2A/2B receptor, this misclassification might lead to a misunderstanding of the physiological and pathological roles of GluN2, especially the GluN2A subunit.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
