Abstract
Zinc finger protein 36 (ZFP36) is an RNA-binding protein that downregulates the translation of certain gene products by inducing the degradation of mRNA. ZFP36 is an immediate-early gene: its transcription is activated directly following appropriate cellular stimuli, without any need for intervening protein synthesis. Prominent mRNA targets of ZFP36 are tumor necrosis factor (TNF), epidermal growth factor (EGF) and c-fos. As defects in the c-fos and EGF pathways have been consistently found in cancers, ZFP36 is thought to be a tumor-suppressor. ZFP36 also is responsible for the suppression of TNF, giving it an additional role in the control of the inflammatory immune response. Thus, studying the regulation and action of ZPF36 may yield insights into mechanisms underlying cancer and inflammatory syndromes. To examine the regulation of ZFP36, two conserved regions upstream of the start of transcription were assayed for their ability to confer serum induction. Using a luciferase reporter gene system in HeLa cells, we show that neither region examined is induced by serum.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
