Abstract
Identifying risk factors for graft loss within 90 days of kidney transplantation in the modern era: A review of single center and UNOS databases
Highlights
Kidney transplantation is the most effective treatment available for patients with end-stage renal disease (ESRD)
Single center and United Network for Organ Sharing (UNOS) data suggest that early graft loss (EGL) occurs more frequently in recipients of sub-optimal allografts
Increased age, elevated body mass index (BMI), and recipient diabetes were significantly associated with higher rates of EGL due to patient death when compared to the non-EGL group (p
Summary
Kidney transplantation is the most effective treatment available for patients with end-stage renal disease (ESRD). Because of the need for more donors, there has been increasing utilization of suboptimal kidneys, which are associated with inferior outcomes [2,3]. It has been suggested that the use of these allografts is linked to early graft loss (EGL) [4]. EGL is defined as graft loss occurring within 90 days of kidney transplantation. It is relatively rare, occurring after approximately 5% of transplantations [5]. Causes of EGL include: patient death, renal artery or vein thrombosis, acute rejection (AR), and primary non-function (PNF). Very short-term outcomes after kidney transplantation are understudied. There have been few reports on risk factors for EGL, and those that have been published are limited to single center analyses [4,5]
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