Abstract
Background Persons with KS and uncontrolled HIV infection have HHV-8 DNA detected more frequently at mucosal sites and plasma [1], but it remains unknown whether the quantity of HHV-8 detected is associated with KS development or HHV-8 transmission. We sought to characterize and determine the correlates of elevated HHV-8 DNA copy number in the oropharynx and plasma of Ugandan adults with and without HIV and KS.
Highlights
Persons with KS and uncontrolled HIV infection have HHV-8 DNA detected more frequently at mucosal sites and plasma [1], but it remains unknown whether the quantity of HHV-8 detected is associated with KS development or HHV-8 transmission
297 participants collected a total of 8,045 oral swabs and 1,392 plasma samples
Higher plasma HHV-8 copy number was associated with KS and HIV infection
Summary
Warren Phipps1,2*, Jackson Orem, Innocent Mutyaba, James Kafeero, Meei-Li Huang, Stacy Selke, Lisa Bunts, Marla Husnik, Anna Wald, Larry Corey, Corey Casper. From 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. From 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 7-8 November 2011
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