Abstract
Background A prolonged QT is a major risk factor for developing Torsades de Pointes, a potentially fatal cardiac dysrhythmia. The prolongation of QT interval may be due to adverse drug reactions. Many drugs such as haloperidol and methadone are known to prolong the QT interval. In effect, it is one of the most common reasons for drug withdrawal from the market [1]. Here, we propose to identify drugs that may promote QT prolongation using electronic medical records.
Highlights
A prolonged QT is a major risk factor for developing Torsades de Pointes, a potentially fatal cardiac dysrhythmia
Materials and methods As an ongoing effort in studying drug effects, Vanderbilt University Medical Center has constructed an anonymized database of medication orders and ECGs of all inpatients admitted for 2 to 30 days from 1999 to 2003
When QT prolongation is detected for a patient, drugs administered 72 hours prior are retrieved for further analysis
Summary
A prolonged QT is a major risk factor for developing Torsades de Pointes, a potentially fatal cardiac dysrhythmia. The prolongation of QT interval may be due to adverse drug reactions. Many drugs such as haloperidol and methadone are known to prolong the QT interval. In effect, it is one of the most common reasons for drug withdrawal from the market [1]. We propose to identify drugs that may promote QT prolongation using electronic medical records
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