Abstract
BackgroundResearch investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied. The aim of this systematic review is to identify the domains and outcomes reported in exercise interventions in oesophagogastric cancer survivors to be included in a Delphi study, with a view to informing the development of a core outcome set (COS).MethodsEMBASE, PubMed, CINHAL, Cochrane Library, SCOPUS, and PEDro were searched up to March 2020 using a predefined search strategy. The outcomes identified during data extraction were categorised using the core areas outlined in the OMERACT Filter 2.0.ResultsFourteen domains and 63 outcomes were identified. The most frequently reported outcomes were in the domains of quality of life using the EORTC-QLQ-C30 questionnaire and the relevant disease-specific modules (100%), exercise capacity/fitness/physical function (100%), anthropometrics (83.33%), physical activity (66.67%), and biomarker analysis (50%).ConclusionThis systematic review quantifies and describes the domains and outcomes examined in exercise interventions in oesophagogastric cancer survivors. Some inconsistency exists within the domains and outcomes used, and little attention was given to nutritional or economic endpoints. In order to develop a COS, a Delphi consensus process with key stakeholders is needed to identify the relevant domains and outcomes for inclusion.
Highlights
Research investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied
core outcome set (COS) have already been developed for clinical effectiveness trials in oesophageal cancer resection surgery [15, 16], no COS exists for exercise interventions in oesophagogastric cancer survivors
The 2015 Cancer and Aging Research Group NCI U13 Meeting provided recommendations for selecting outcomes for exercise intervention trials for older adults with cancer including decreased hospitalisations, reduced cancer treatment toxicity, disease prevention, disease-free survival or overall survival, and cost saving [19]. While these lists identify a considerable list of pertinent outcomes relevant to exercise interventions, there is an absence of standardisation and they lack specificity to the physical and nutritional concerns that are unique to oesophagogastric cancer survivorship
Summary
Research investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied. The 2015 Cancer and Aging Research Group NCI U13 Meeting provided recommendations for selecting outcomes for exercise intervention trials for older adults with cancer including decreased hospitalisations, reduced cancer treatment toxicity, disease prevention, disease-free survival or overall survival, and cost saving [19]. While these lists identify a considerable list of pertinent outcomes relevant to exercise interventions, there is an absence of standardisation and they lack specificity to the physical and nutritional concerns that are unique to oesophagogastric cancer survivorship
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